Identification of Sphingomyelinase on the Surface of Chlamydia pneumoniae: Possible Role in the Entry into Its Host Cells

We have recently suggested a novel mechanism, autoendocytosis, for the entry of certain microbes into their hosts, with a key role played by the sphingomyelinase-catalyzed topical conversion of sphingomyelin to ceramide, the differences in the biophysical properties of sword these two lipids providing the driving force.The only requirement for such

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Butyric Acid Added Apically to Intestinal Caco-2 Cells Elevates Hepatic ApoA-I Transcription and Rescues Lower ApoA-I Expression in Inflamed HepG2 Cells Co-Cultured in the Basolateral Compartment

Apolipoprotein A-I Shower Gels (ApoA-I) concentrations are decreased during inflammation, which may reduce high-density lipoprotein (HDL) functionality.Thus, rescuing ApoA-I concentrations during inflammation might help to prevent atherosclerosis.Recent studies have shown that butyric acid (C4) has anti-inflammatory effects and rescues ApoA-I produ

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